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Year Number of Results
1980 1
1991 1
1992 1
1998 1
2002 1
2005 1
2006 1
2015 2
2016 1
2018 1
2019 1
2020 1
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2023 2
2024 0

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16 results

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Page 1
Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer.
Lin Y, Nakatochi M, Hosono Y, Ito H, Kamatani Y, Inoko A, Sakamoto H, Kinoshita F, Kobayashi Y, Ishii H, Ozaka M, Sasaki T, Matsuyama M, Sasahira N, Morimoto M, Kobayashi S, Fukushima T, Ueno M, Ohkawa S, Egawa N, Kuruma S, Mori M, Nakao H, Adachi Y, Okuda M, Osaki T, Kamiya S, Wang C, Hara K, Shimizu Y, Miyamoto T, Hayashi Y, Ebi H, Kohmoto T, Imoto I, Kasugai Y, Murakami Y, Akiyama M, Ishigaki K, Matsuda K, Hirata M, Shimada K, Okusaka T, Kawaguchi T, Takahashi M, Watanabe Y, Kuriki K, Kadota A, Okada R, Mikami H, Takezaki T, Suzuki S, Yamaji T, Iwasaki M, Sawada N, Goto A, Kinoshita K, Fuse N, Katsuoka F, Shimizu A, Nishizuka SS, Tanno K, Suzuki K, Okada Y, Horikoshi M, Yamauchi T, Kadowaki T, Yu H, Zhong J, Amundadottir LT, Doki Y, Ishii H, Eguchi H, Bogumil D, Haiman CA, Le Marchand L, Mori M, Risch H, Setiawan VW, Tsugane S, Wakai K, Yoshida T, Matsuda F, Kubo M, Kikuchi S, Matsuo K. Lin Y, et al. Nat Commun. 2020 Jun 24;11(1):3175. doi: 10.1038/s41467-020-16711-w. Nat Commun. 2020. PMID: 32581250 Free PMC article.
The lead single nucleotide polymorphism (SNP) at 16p12.3 is rs78193826 (odds ratio = 1.46, 95% confidence interval = 1.29-1.66, P = 4.28 10(-9)), an Asian-specific, nonsynonymous glycoprotein 2 (GP2) gene variant. Associations between selected GP2 gene variants and …
The lead single nucleotide polymorphism (SNP) at 16p12.3 is rs78193826 (odds ratio = 1.46, 95% confidence interval = 1.29-1.66, P = 4.28 10( …
Risk of bleeding and restenosis among chronic kidney disease patients undergoing percutaneous coronary intervention.
Attallah N, Yassine L, Fisher K, Yee J. Attallah N, et al. Clin Nephrol. 2005 Dec;64(6):412-8. doi: 10.5414/cnp64412. Clin Nephrol. 2005. PMID: 16370153
RESULTS: The incidence of major bleeding within the first month (3.4% in normal kidney function patients (Gp 1), 4.8% for CKD Stages 1 and 2 patients (Gp2), 5.2% for CKD Stage 3 patients (Gp3), 6.1% for CKD Stage 4 patients (Gp4) and 9.3% for CKD Stage 5 patients (G …
RESULTS: The incidence of major bleeding within the first month (3.4% in normal kidney function patients (Gp 1), 4.8% for CKD Stages …
Equine herpesvirus type 1 devoid of gM and gp2 is severely impaired in virus egress but not direct cell-to-cell spread.
Rudolph J, Osterrieder N. Rudolph J, et al. Virology. 2002 Feb 15;293(2):356-67. doi: 10.1006/viro.2001.1277. Virology. 2002. PMID: 11886256 Free article.
The mutant RacH virus (H Delta gp2) reconstituted from pRacH lacked gene 71 and did not express gp2 as assayed by indirect immunofluorescence analysis using gp2-specific monoclonal antibodies. The H Delta gp2 virus exhibited 10-fold reduced extracellul …
The mutant RacH virus (H Delta gp2) reconstituted from pRacH lacked gene 71 and did not express gp2 as assayed by indirect imm …
Association between immunoglobulin G N-glycosylation and lupus nephritis in female patients with systemic lupus erythematosus: a case-control study.
Lu X, Wang L, Wang M, Li Y, Zhao Q, Shi Y, Zhang Y, Wang Y, Wang W, Ji L, Hou H, Li D. Lu X, et al. Front Immunol. 2023 Sep 21;14:1257906. doi: 10.3389/fimmu.2023.1257906. eCollection 2023. Front Immunol. 2023. PMID: 37809087 Free PMC article.
RESULTS: There were significant differences in 9 initial glycans (GP2, GP4, GP6, GP8, GP10, GP14, GP16, GP18 and GP23) between women with SLE with and without LN (P < 0.05). ...
RESULTS: There were significant differences in 9 initial glycans (GP2, GP4, GP6, GP8, GP10, GP14, GP16, GP18 and GP23) between women …
A structured interdomain linker directs self-polymerization of human uromodulin.
Bokhove M, Nishimura K, Brunati M, Han L, de Sanctis D, Rampoldi L, Jovine L. Bokhove M, et al. Proc Natl Acad Sci U S A. 2016 Feb 9;113(6):1552-7. doi: 10.1073/pnas.1519803113. Epub 2016 Jan 25. Proc Natl Acad Sci U S A. 2016. PMID: 26811476 Free PMC article.
Uromodulin (UMOD)/Tamm-Horsfall protein, the most abundant human urinary protein, plays a key role in chronic kidney diseases and is a promising therapeutic target for hypertension. Via its bipartite zona pellucida module (ZP-N/ZP-C), UMOD forms extracellular filame …
Uromodulin (UMOD)/Tamm-Horsfall protein, the most abundant human urinary protein, plays a key role in chronic kidney diseases …
[Tamm-Horsfall protein].
Peraldi MN. Peraldi MN. Nephrologie. 1992;13(1):7-11. Nephrologie. 1992. PMID: 1579196 Review. French.
Recently, the main protein secreted in the rat pancreatic juice has been cloned (GP2). It is 88% homologous to TH protein, some of GP2 properties are the same as TH properties. ...
Recently, the main protein secreted in the rat pancreatic juice has been cloned (GP2). It is 88% homologous to TH protein, some of …
Immune Responses of HLA Highly Sensitized and Nonsensitized Patients to Genetically Engineered Pig Cells.
Zhang Z, Hara H, Long C, Iwase H, Qi H, Macedo C, Mangiola M, Zeevi A, Ezzelarab M, Ayares D, Cooper DKC, Wijkstrom M. Zhang Z, et al. Transplantation. 2018 May;102(5):e195-e204. doi: 10.1097/TP.0000000000002060. Transplantation. 2018. PMID: 29266033 Free PMC article.
BACKGROUND: We investigated in vitro whether HLA highly sensitized patients with end-stage renal disease will be disadvantaged immunologically after a genetically engineered pig kidney transplant. METHODS: Blood was drawn from patients with a calculated panel-reactive anti …
BACKGROUND: We investigated in vitro whether HLA highly sensitized patients with end-stage renal disease will be disadvantaged immunological …
Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH.
Stsiapanava A, Xu C, Nishio S, Han L, Yamakawa N, Carroni M, Tunyasuvunakool K, Jumper J, de Sanctis D, Wu B, Jovine L. Stsiapanava A, et al. Nat Struct Mol Biol. 2022 Mar;29(3):190-193. doi: 10.1038/s41594-022-00729-3. Epub 2022 Mar 10. Nat Struct Mol Biol. 2022. PMID: 35273390 Free PMC article.
Glycoprotein 2 (GP2) and uromodulin (UMOD) filaments protect against gastrointestinal and urinary tract infections by acting as decoys for bacterial fimbrial lectin FimH. By combining AlphaFold2 predictions with X-ray crystallography and cryo-EM, we show that these protein …
Glycoprotein 2 (GP2) and uromodulin (UMOD) filaments protect against gastrointestinal and urinary tract infections by acting as decoy …
Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population.
Suzuki K, Akiyama M, Ishigaki K, Kanai M, Hosoe J, Shojima N, Hozawa A, Kadota A, Kuriki K, Naito M, Tanno K, Ishigaki Y, Hirata M, Matsuda K, Iwata N, Ikeda M, Sawada N, Yamaji T, Iwasaki M, Ikegawa S, Maeda S, Murakami Y, Wakai K, Tsugane S, Sasaki M, Yamamoto M, Okada Y, Kubo M, Kamatani Y, Horikoshi M, Yamauchi T, Kadowaki T. Suzuki K, et al. Nat Genet. 2019 Mar;51(3):379-386. doi: 10.1038/s41588-018-0332-4. Epub 2019 Feb 4. Nat Genet. 2019. PMID: 30718926

Among the 28 missense variants, three previously unreported variants had distinct minor allele frequency (MAF) spectra between people of Japanese and European ancestry (MAF(JPN) > 0.05 versus MAF(EUR) < 0.01), including missense variants in genes related to pancreatic acina

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Among the 28 missense variants, three previously unreported variants had distinct minor allele frequency (MAF) spectra between people of Jap …
The biochemical properties of basement membrane components in health and disease.
Johnson LD. Johnson LD. Clin Biochem. 1980 Oct;13(5):204-8. doi: 10.1016/s0009-9120(80)80024-5. Clin Biochem. 1980. PMID: 7006856 Review.
Biochemically it is composed of Type IV collagen, several noncollagenous glycoproteins including laminin, fibronectin, GP-2 and PYS glycoprotein, and heparan sulfate. Morphologic changes are commonplace in a number of renal diseases. In diabetic glomerular disease, the bas …
Biochemically it is composed of Type IV collagen, several noncollagenous glycoproteins including laminin, fibronectin, GP-2 and PYS glycopro …
16 results